Biological Systems at the Molecular Level

Engineering Approaches Toward Biological Information Integration at the Systems Level

Our understanding of biological systems has improved dramatically due to decades of exploration. This process has been accelerated even further during the past ten years, mainly due to the genome projects, new technologies such as microarray, and developments in proteomics. These advances have generated huge amounts of data describing biological systems from different aspects. Still, integratin...

Symmetry and Function of Biological Systems at the Macromolecular Level

This symposium has been organized with some care, to bring together those workers in biology whose outlook is both "molecular" and who have some facility in speculation. The macromolecules whose symmetry and function we are invited to consider are proteins or protein-associated structures such as membranes. What symmetry can we expect in the face of the clear asymmetry implied in the primary st...

Elucidating a biological role for chromium at a molecular level.

Chromium is an essential trace element for mammals and is required for maintenance of proper carbohydrate and lipid metabolism. However, elucidating its function at a molecular level has proved to be problematic. Recent research has revealed that the chromium-binding oligopeptide chromodulin may play a unique role in the autoamplification of insulin signaling. Attempts to develop chromium-conta...

The Journal of Nutrition Symposium: Advances in Understanding of the Biological Role of Biotin at the Clinical, Biochemical, and Molecular Level Biotin Sensing at the Molecular Level

Biotin influences transcription in organisms from bacteria to humans. The enzyme, biotin protein ligase, which catalyzes post-transcriptional biotin addition to biotin-dependent carboxylases, plays a central roll in transmitting the demand for biotin to gene expression. The molecular mechanism of this communication in bacteria is well understood and involves competing protein:protein interactio...

Ferroelectricity at molecular level